Polyphosphates inhibit extracellular matrix mineralization in MC3T3-E1 osteoblast cultures
نویسندگان
چکیده
منابع مشابه
Inositol hexakisphosphate inhibits mineralization of MC3T3-E1 osteoblast cultures.
Inositol hexakisphosphate (IP6, phytic acid) is an endogenous compound present in mammalian cells and tissues. Differentially phosphorylated forms of inositol are well-documented to have important roles in signal transduction, cell proliferation and differentiation, and IP6 in particular has been suggested to inhibit soft tissue calcification (specifically renal and vascular calcification) by b...
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Pycnogenol (PYC) is a natural plant extract from the bark of Pinus pinaster Atiton that has potent anti-oxidant activities. Recent studies have shown that orally administered PYC can increase the biomechanical strength of bone and bone mineral density in ovariectomized rats. However, the effect of PYC on osteoblast mineralization has not yet been examined. We studied the differentiation and min...
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We examined the effects of various endothelins on the mineralization of mouse clonal preosteoblastic MC3T3-E1 cells. MC3T3-E1 cells expressed mRNAs for endothelin (ET)-1 and the A-type receptor for ET (ETA). A pharmacological study also demonstrated the predominant expression of the ETA receptor. Northern blotting analysis revealed that ETs decreased the expression of mRNA for osteocalcin, whic...
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Bone homeostasis is tightly regulated to balance bone formation and bone resorption. Many anabolic drugs are used as bone-targeted therapeutic agents for the promotion of osteoblast-mediated bone formation or inhibition of osteoclast-mediated bone resorption. Previous studies showed that ginsenoside Re has the effect of the suppression of osteoclast differentiation in mouse bone-marrow derived ...
متن کاملIntrinsic mechanical properties of the extracellular matrix affect the behavior of pre-osteoblastic MC3T3-E1 cells.
Mechanical cues present in the ECM have been hypothesized to provide instructive signals that dictate cell behavior. We probed this hypothesis in osteoblastic cells by culturing MC3T3-E1 cells on the surface of type I collagen-modified hydrogels with tunable mechanical properties and assessed their proliferation, migration, and differentiation. On gels functionalized with a low type I collagen ...
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ژورنال
عنوان ژورنال: Bone
سال: 2013
ISSN: 8756-3282
DOI: 10.1016/j.bone.2013.01.020